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Current guidelines on the use of antiemetics for prevention and amelioration of nausea and vomiting should be considered. Since the growth of normal body cells may also be affected by cyclophosphamide, other effects will also occur. Monitoring and Testing While Taking Cyclophosphamide You will be checked regularly by your doctor while you are taking cyclophosphamide, to monitor side effects and check your response to therapy.
Cyclophosphamide-induced myelosuppression can cause leukopenia, neutropenia, thrombocytopenia associated with a higher risk of bleeding eventsand anaemia. Stomatitis Administration of cyclophosphamide may cause stomatitis oral mucositis - source. Paravenous Administration The cytostatic effect of cyclophosphamide occurs after its activation, which takes place mainly in the liver.
Some of these may be serious and must be reported to your doctor. Abstract Background Unintended exposure to antitumor agents from an oral medicine may place healthcare workers and patients taking medicine at risk.
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Current guidelines on measures for prevention and amelioration of stomatitis should be considered. Close haematological monitoring is required for all patients during treatment.
Haemopericardium has occurred secondary to hemorrhagic myocarditis and myocardial necrosis. Cardiotoxicity, Use in Patients with Cyclophosphamide oral tablet Disease Myocarditis and myopericarditis, which may be accompanied by significant pericardial effusion and cardiac tamponade, have been reported with cyclophosphamide therapy and have led to severe, sometimes fatal congestive heart failure. The bone marrow recovers relatively quickly, and the levels of peripheral blood cell counts normalize, as a rule, after approximately 20 days.
Animal data indicate that exposure of oocytes during follicular development may result in a decreased rate of implantations and viable pregnancies, and in an increased risk of malformations.
It is usually necessary to discontinue cyclophosphamide therapy in instances of severe hemorrhagic cystitis. Cyclophosphamide, Oral tablet, Blister pack Background Although antitumor agents are very widely used for the treatment of cancer, they pose a risk to healthcare workers who handle the drugs or work in their vicinity and in patients, even at very low concentration.
The scheduling of chemotherapy is set based on the type of cells, rate at which they divide, and the time at which a given drug is likely to be effective. Avoid sun exposure.
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